Phosphatidylserine
Phospholipid supporting neuronal membrane integrity; best evidence for cortisol attenuation during exercise & memory in older adults.
cognitionrecoverystresslongevity
Evidence last reviewed: 04 Apr 2026
Trade-offs & context
Known concerns, timing considerations, & interactions
Hormones
Significant cortisol attenuation — avoid if cortisol is already low or adrenal insufficiency is suspected
Tolerance
GI discomfort at high doses; fat-soluble — take with food
Context: doses >800mg
Dot colour: ●High concern ●Moderate ● Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Hormonal
Cortisol
Cognitive
Memory
Evidence
1 record
Exercise-induced cortisol / cognitive stress
Healthy adults; older adults • RCTs
PUBMEDModerate
Attenuates post-exercise cortisol spike; some benefit to memory in cognitively declining adults.
Dose: 400 mgDuration: 2–12 weeks
Fat-soluble; take with food.
Forms
Soy- or sunflower-derived PS
Soy most studied; sunflower for allergen-free.
Stacks containing Phosphatidylserine
Public community stacks that include this ingredient.
stresscognitivefocus
Stress & Cognitive Support
by@athlete
Rhodiola rosea & phosphatidylserine are combined to support stress reduction & cognitive function. Rhodiola rosea is an adaptogen that enhances resilience to stress, while phosphatidylserine supports cognitive performance & reduces stress-related cortisol levels.
Rhodiola Rosea
200mg
Phosphatidylserine
100mg
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