StackTerminal.Health

BETA

Phosphatidylcholine

Phosphatidylcholine is a major phospholipid component of cell membranes and serves as a direct choline source for acetylcholine synthesis. It is used for liver protection and cognitive function preservation, and as a delivery vehicle for other lipophilic nutrients.

liver-healthcognitivenootropicnutritional
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Metabolic
Blood GlucoseHbA1c
Cognitive
Cognitive Function
Evidence
3 records
Choline metabolite levels
General populationMendelian randomization
PUBMEDModerate

Phosphatidylcholine was associated with increased choline metabolite levels, which may mediate effects on type 2 diabetes.

Dose: 2000 mg
Cognitive function
General populationSystematic review
PUBMEDLow

Phosphatidylcholine supplementation is suggested to support cognitive function through choline availability.

Dose: 2000 mg
The review highlights the role of choline in cognitive development.
Ulcerative colitis remission
Patients with ulcerative colitisMeta-analysis
PUBMEDHigh

Phosphatidylcholine improved remission rates and clinical outcomes significantly over placebo.

Dose: 2000 mgForm: Delayed-release
Delayed intestinal release formulation was used.
Forms
Lecithin
Common food form, often derived from soy or sunflower.
Delayed-release
Used clinically for targeted intestinal delivery.

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