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Oxiracetam

Oxiracetam is a water-soluble racetam that may enhance memory & cognitive function, particularly in tasks involving spatial & logical reasoning. It is primarily used by individuals seeking cognitive enhancement.

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Evidence last reviewed: 05 Apr 2026

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Bottom line

Oxiracetam is a cognitive enhancer that may improve memory and reasoning skills. While evidence supports its use in certain populations, results vary and more research is needed.

Summarized study outcomes with population, design, grade, and effect data.

4 recordsBest grade:Moderate
Memory enhancementCognitive function improvementCognitive decline preventionCognitive function in vascular cognitive impairment

Oxiracetam has shown moderate effectiveness in improving cognitive function in specific populations, such as those with traumatic brain injury and vascular cognitive impairment. However, the evidence for its use in preventing cognitive decline and enhancing memory in dementia is less robust, indicating a need for further studies.

Biomarkers studied
Cognitive
MemoryCognitive Function
Memory enhancement
Patients with mild to moderate dementia · RCT
Low

Oxiracetam showed potential in enhancing memory in patients with mild to moderate dementia.

Dose: 1600 mgForm: Oxiracetam
Citation: Villardita et al. (1987). Clinical and neuropsychological study with oxiracetam versus placebo in patients with mild to moderate dementia. Nature Reviews Neurology.
Cognitive function improvement
Patients with traumatic brain injury · RCT
Moderate

Oxiracetam showed improvement in cognitive function as measured by the LOTCA score.

Dose: 6000 mgDuration: 90 daysForm: Oxiracetam
Citation: Wang et al. (2024). Development and validation of a chiral UPLC-MS/MS method for quantifying S-Oxiracetam and R-Oxiracetam in human plasma, urine and feces: Application to a phase-I clinical pharmacokinetic study. Frontiers in Neuroscience.
Cognitive decline prevention
Patients post-stroke · RCT
Low

Oxiracetam may have a modest effect on preventing cognitive decline in post-stroke patients.

Dose: 1600 mgDuration: 36 weeksForm: Oxiracetam
Citation: Hjorther et al. (1987). Organic brain syndrome treated with oxiracetam. A double-blind randomized controlled trial. Experimental Neurology.
Cognitive function in vascular cognitive impairment
Patients with vascular cognitive impairment · RCT
Moderate

Oxiracetam was found to be effective in improving cognitive function in patients with vascular cognitive impairment.

Dose: 1600 mgForm: Oxiracetam
Citation: Lim et al. (2023). Efficacy and safety of oxiracetam in patients with vascular cognitive impairment: A multicenter, randomized, double-blinded, placebo-controlled, phase IV clinical trial. European Journal of Trauma and Emergency Surgery.

Stacks containing Oxiracetam

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cognitiveneuroplasticityfocus

Cognitive & Neuroplasticity Enhancement

by@athlete

Oxiracetam & lion's mane mushroom are combined to enhance cognitive function & neuroplasticity. Oxiracetam is known for its memory-enhancing effects, while lion's mane mushroom supports neurogenesis & cognitive performance.

Oxiracetam
800mg
Lion's Mane Mushroom
500mg
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