StackTerminal.Health

BETA

L-Ornithine

L-Ornithine is a non-proteinogenic amino acid that plays a role in the urea cycle, helping to clear ammonia and reduce exercise-induced fatigue. It may improve endurance performance and sleep quality, and is often used with arginine to enhance growth hormone secretion.

performanceendurancerecoverysleepgrowth-hormone
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Hormonal
Growth Hormone
Performance
Muscle Endurance
Inflammation
TNF-α
Evidence
4 records
hepatic encephalopathy improvement
patients with cirrhosisRCT
PUBMEDModerate

L-ornithine L-aspartate improved hepatic encephalopathy grades and reduced inflammatory markers.

Dose: 2000 mgDuration: 5 daysForm: L-Ornithine L-Aspartate
growth hormone secretion
healthy adultsRCT
PUBMEDLow

L-ornithine, often combined with arginine, may enhance growth hormone secretion.

Dose: 2000 mgDuration: single doseForm: L-OrnithineTiming: before bed
Often used in combination with arginine.
ammonia clearance
patients with chronic liver diseaseRCT
PUBMEDModerate

Intravenous L-ornithine L-aspartate improved grades of hepatic encephalopathy and reduced serum ammonia levels.

Dose: 2000 mgDuration: 5 daysForm: L-Ornithine L-Aspartate
exercise-induced fatigue
healthy volunteersRCT
PUBMEDModerate

L-ornithine supplementation reduced physical fatigue by modulating lipid and amino acid metabolism.

Dose: 2000 mgDuration: single doseForm: L-OrnithineTiming: before exercise
Forms
L-Ornithine
Commonly used in supplements for ammonia clearance and fatigue reduction.
L-Ornithine L-Aspartate
Used in clinical settings for hepatic encephalopathy and liver health.

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