Nicotinamide Riboside (NR)
NAD+ precursor similar to NMN; more human trial data available. Raises NAD+ reliably.
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Evidence last reviewed: 04 Apr 2026
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Trade-offs & context
Known concerns, timing considerations, & interactions
Tolerance
Nausea and flushing at higher doses
Context: doses >1000mg
Note
Same theoretical NAD+-fuelled cell proliferation concern as NMN — clinical significance unknown
Cardiovascular
Modest blood pressure lowering — relevant for those on antihypertensives
Dot colour: ●High concern ●Moderate ● Low / note
Evidence
1 record
NAD+ levels / cardiovascular markers
Healthy adults; older adults • RCTs
PUBMEDModerate
Consistent NAD+ elevation; some cardioprotective signals; no major adverse events in trials to date.
Dose: 500 mgDuration: 6–12 weeks
NMN vs NR debate ongoing; both raise NAD+ effectively.
Forms
NR chloride (Niagen)
Most studied commercial form.
Stacks containing Nicotinamide Riboside (NR)
Public community stacks that include this ingredient.
No public stacks include this ingredient yet.