StackTerminal.Health

BETA

Niacin (Vitamin B3)

Niacin is an essential B vitamin that supports energy metabolism and is used in pharmacological doses to improve lipid profiles by raising HDL cholesterol and lowering triglycerides and LDL cholesterol. It is also used as nicotinamide for skin health and NAD synthesis support.

cardiovascularmetabolicenergynutritional
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
HDL CholesterolLDL CholesterolTriglycerides
Cognitive
Neuroprotection / NGF
Evidence
4 records
Lipid profile improvement
Patients with coronary artery disease • Systematic review
PUBMEDHigh

Niacin therapy was found to improve lipid profiles by raising HDL cholesterol and lowering triglycerides and LDL cholesterol.

Dose: 500 mg
Citation: Duggal et al. (2010). Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
NAD+ synthesis support
General population • Systematic review
PUBMEDModerate

Niacin is a precursor to NAD+, supporting cellular energy metabolism.

Dose: 500 mgForm: Nicotinamide
Citation: Park et al. (2017). Niacin intake and risk of skin cancer in US women and men.
Glaucoma risk reduction
Individuals with high niacin consumption • Systematic review and Meta-analysis
PUBMEDModerate

Higher niacin consumption was associated with a lower risk of glaucoma.

Dose: 500 mg
Citation: Nicola et al. (2024). Systematic Review and Meta-Analysis on the Association Between Daily Niacin Intake and Glaucoma.
Skin cancer chemoprevention
Individuals at risk for non-melanoma skin cancers • Systematic review and Meta-analysis
PUBMEDModerate

Nicotinamide was found to have a protective role against skin cancer recurrence.

Dose: 500 mgForm: Nicotinamide
Citation: Tosti et al. (2023). The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
Forms
Nicotinic Acid
Common form used for lipid profile improvement.
Nicotinamide
Used for skin health and NAD synthesis.
Extended-Release Niacin
Formulated to reduce flushing side effects.

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