MSM (Methylsulfonylmethane)

Studied for joint pain/function outcomes; evidence includes placebo-controlled trials with modest improvements in knee OA symptom scores.

womens-healthrecoverylongevity

Dosing model

FLATFixed dose (no body-weight scaling).

Min dose

3000 mg

Max dose

6000 mg

Rounding

500 mg

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Stacks containing MSM (Methylsulfonylmethane)

Public community stacks that include this ingredient.

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endurancestrengthrecovery

Joint & Training Resilience (Low-Drama)

by@athlete

Simple add-ons for soreness/joint comfort signals during heavy training blocks.

Curcumin Extract

1000mg

MSM (Methylsulfonylmethane)

6000mg

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Evidence

2 records

Knee osteoarthritis pain/function

Adults with knee OA • RCT

Low

Double-blind placebo-controlled trial reported improvements in pain and physical function with MSM 3 g twice daily for 12 weeks.

Dose: 6000 mg • Duration: 12 weeks

Citation: Kim LS, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14(3):286-294.

Knee joint quality of life / mild knee pain

Healthy adults with mild knee pain (not clinical OA) • RCT

Low

Double-blind RCT (n=88) found MSM 2,000 mg/day for 12 weeks significantly improved total JKOM knee symptom scores (p=0.046) and self-reported health condition (p=0.032) vs placebo in participants with mild knee pain.

Dose: 2000 mg • Duration: 12 weeks

Citation: Butawan M, et al. Methylsulfonylmethane improves knee quality of life in participants with mild knee pain: a randomized, double-blind, placebo-controlled trial. Nutrients. 2023;15(14):3227.

Forms

Capsule / powder

Often split dose