StackTerminal.Health

BETA

MSM (Methylsulfonylmethane)

Studied for joint pain/function outcomes; evidence includes placebo-controlled trials with modest improvements in knee OA symptom scores.

womens-healthrecoverylongevity
Evidence last reviewed: 04 Apr 2026
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Evidence
2 records
Knee osteoarthritis pain/function
Adults with knee OARCT
PUBMEDLow

Double-blind placebo-controlled trial reported improvements in pain & physical function with MSM 3 g twice daily for 12 weeks.

Dose: 6000 mgDuration: 12 weeks
Knee joint quality of life / mild knee pain
Healthy adults with mild knee pain (not clinical OA)RCT
PUBMEDLow

Double-blind RCT (n=88) found MSM 2,000 mg/day for 12 weeks significantly improved total JKOM knee symptom scores (p=0.046) & self-reported health condition (p=0.032) vs placebo in participants with mild knee pain.

Dose: 2000 mgDuration: 12 weeks
Forms
Capsule / powder
Often split dose

Stacks containing MSM (Methylsulfonylmethane)

Public community stacks that include this ingredient.

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joint-healthanti-inflammatorypain

Combining MSM with Serrapeptase can support joint health and reduce inflammation. MSM is known for its joint-supporting properties, while Serrapeptase provides anti-inflammatory and pain-relieving effects.

MSM (Methylsulfonylmethane)
3000mg
Serrapeptase
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jointrecoverylongevity

Glucosamine & MSM are combined to support joint health & recovery. Glucosamine aids in cartilage repair & reduces joint pain, while MSM provides anti-inflammatory support & enhances joint flexibility.

Glucosamine
1500mg
MSM (Methylsulfonylmethane)
3000mg
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endurancestrengthrecovery

Simple add-ons for soreness/joint comfort signals during heavy training blocks.

Curcumin Extract
1000mg
MSM (Methylsulfonylmethane)
6000mg
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