StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Mirtazapine

Mirtazapine is a noradrenergic & specific serotonergic antidepressant (NaSSA) used primarily for treating major depressive disorder, particularly in patients with insomnia or poor appetite. It is known for its rapid onset of action & ability to improve sleep & stimulate appetite.

mental-healthdepressionsleepappetite
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Metabolic
Body WeightBMI
Cognitive
Mood / Wellbeing
Evidence
3 records
Depression symptom reduction
Adults with major depressive disorderSystematic review
PUBMEDHigh

Mirtazapine was found to be more efficacious than placebo in treating major depressive disorder.

Dose: 30 mg
Treatment-resistant depression
Adults with treatment-resistant major depressive disorderSystematic review
PUBMEDModerate

Mirtazapine showed higher discontinuation rates compared to placebo in treatment-resistant depression.

Dose: 30 mg
Higher discontinuation rates may indicate side effects or lack of efficacy in this population.
Weight gain
Adults with major depressive disorderSystematic review
PUBMEDModerate

Mirtazapine is associated with weight gain in patients.

Dose: 30 mg
Weight gain is a common side effect of mirtazapine.
Forms
Tablet
Commonly prescribed form for oral administration.
Orally Disintegrating Tablet
Dissolves on the tongue for ease of use.

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