StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Mescaline

Mescaline is a phenethylamine psychedelic primarily found in peyote & San Pedro cacti, known for its serotonin 2A receptor agonism. It has limited clinical research but shows preliminary potential in treating depression & substance use disorders.

mental-healthdepressionneuroplasticity
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Mood / Wellbeing
Evidence
3 records
Substance Use Disorders
Individuals with substance use disordersSystematic review
PUBMEDVery low

Psychedelics, including mescaline, may offer novel treatment opportunities for substance use disorders.

Dose: 300 mg
The review discusses the potential of psychedelics in treating substance use disorders.
Depression
Patients with major depressive disorderMeta-analysis
PUBMEDLow

There is currently only low-level evidence to support the efficacy & safety of psychedelics for major depressive disorder.

Dose: 300 mg
The meta-analysis indicates low-level evidence for the use of psychedelics in depression.
Depression
Patients with treatment-resistant depressionSystematic review
PUBMEDLow

Emerging evidence indicates that psychedelics can exert antidepressant effects through multiple neurobiological & psychological mechanisms.

Dose: 300 mg
The review highlights the potential of psychedelics, including mescaline, for antidepressant effects.
Forms
Peyote
Natural source, traditional use in Native American rituals.
San Pedro
Natural source, used in traditional Andean rituals.
Synthetic Mescaline
Pure compound, used in research settings.

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