StackTerminal.Health

BETA

Manganese

Manganese is an essential trace mineral that supports bone formation, collagen synthesis, carbohydrate metabolism, and antioxidant defense, primarily benefiting bone health and metabolic functions.

antioxidantbone-healthmetabolicnutritional
Evidence last reviewed: 20 Apr 2026
Supplement note
Private note on this supplement

Save how you reacted, what dose worked, what to watch for, or anything you want to remember later in your Notes tab.

Sign in to keep a private note on Manganese.
Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Cognitive Function
Inflammation
Oxidative Stress (MDA)
Immune
Immune Function
Evidence
4 records
Antioxidant enzyme function
General populationSystematic review
PUBMEDModerate

Manganese is critical for the function of antioxidant enzymes such as MnSOD, which plays a role in protecting cells from oxidative damage.

Dose: 5 mg
Bone health
General populationSystematic review
PUBMEDModerate

Manganese supports bone formation and collagen synthesis, contributing to overall bone health.

Dose: 5 mg
Cognitive performance
AdultsMeta-analysis
PUBMEDLow

Manganese exposure has been associated with cognitive performance, though further interventional studies are needed.

Dose: 5 mg
Antitumor immune responses
Cancer patientsSystematic review
PUBMEDLow

Manganese is critical for antitumor immune responses via the cGAS-STING pathway, potentially improving the efficacy of clinical immunotherapy.

Dose: 5 mg
Forms
Manganese sulfate
Commonly used in supplements for its high solubility.
Manganese gluconate
Often used for better absorption.
Manganese citrate
Preferred for its bioavailability.

Stacks containing Manganese

Public community stacks that include this ingredient.

Explore all stacks →
No public stacks include this ingredient yet.