StackTerminal.Health

Magnesium L-Threonate

Magnesium L-threonate is a novel magnesium compound engineered to cross the blood-brain barrier, elevating cerebrospinal fluid magnesium and synaptic density; human RCTs demonstrate improvements in cognitive performance, memory, and sleep quality in adults.

cognitiveneuroprotectivesleeplongevitybrain-health
Dosing model
FLATFixed dose (no body-weight scaling).
Min dose
1500 mg
Max dose
2000 mg
Rounding
250 mg
Buy this ingredient← Back

Stacks containing Magnesium L-Threonate

Public community stacks that include this ingredient.

Explore all stacks →
No public stacks include this ingredient yet.
Evidence
2 records
Cognitive performance and memory in healthy adults
Healthy Chinese adults aged 18–65 years • double-blind placebo-controlled RCT
Low

A 30-day double-blind RCT (n=109) found Magtein®PS (magnesium L-threonate-based formula) produced significant improvements versus placebo across all 5 subcategories of the Clinical Memory Test and the overall memory quotient; older participants showed greater cognitive gains than younger participants.

Dose: 2000 mg • Duration: 30 days
Citation: Zhang C, Hu Q, Li S, et al. A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients. 2022;14(24):5235.
Product used was a combination formula (MgT + phosphatidylserine + vitamins C and D); pure MgT contribution cannot be fully isolated.
Sleep quality and daytime functioning in adults with sleep problems
Adults aged 35–55 with self-reported sleep difficulties • RCT
Low

A 21-day RCT (n=80) of magnesium L-threonate (1 g/day) found the treatment group maintained sleep quality while placebo declined; objective Oura ring data showed significant improvements in deep sleep, REM sleep, and light sleep duration; mood, energy, alertness, and daily productivity were also improved.

Dose: 1500 mg • Duration: 21 days
Citation: Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X. 2024;8:100121.
Forms