StackTerminal.Health

BETA

Magnesium L-Threonate

Magnesium L-threonate is a novel magnesium compound engineered to cross the blood-brain barrier, elevating cerebrospinal fluid magnesium & synaptic density; human RCTs demonstrate improvements in cognitive performance, memory, & sleep quality in adults.

cognitiveneuroprotectivesleeplongevitybrain-health
Evidence last reviewed: 04 Apr 2026
Supplement note
Private note on this supplement

Save how you reacted, what dose worked, what to watch for, or anything you want to remember later in your Notes tab.

Sign in to keep a private note on Magnesium L-Threonate.
Biomarkers studied
Outcomes directly measured across the evidence records below
Sleep
Deep Sleep (SWS)REM SleepSleep DurationSleep Quality (subjective)
Cognitive
Cognitive FunctionMemoryMood / Wellbeing
Evidence
2 records
Cognitive performance & memory in healthy adults
Healthy Chinese adults aged 18–65 yearsdouble-blind placebo-controlled RCT
PUBMEDLow

A 30-day double-blind RCT (n=109) found Magtein®PS (magnesium L-threonate-based formula) produced significant improvements versus placebo across all 5 subcategories of the Clinical Memory Test & the overall memory quotient; older participants showed greater cognitive gains than younger participants.

Dose: 2000 mgDuration: 30 daysForm: Magtein®
Product used was a combination formula (MgT + phosphatidylserine + vitamins C & D); pure MgT contribution cannot be fully isolated.
Sleep quality & daytime functioning in adults with sleep problems
Adults aged 35–55 with self-reported sleep difficultiesRCT
PUBMEDLow

A 21-day RCT (n=80) of magnesium L-threonate (1 g/day) found the treatment group maintained sleep quality while placebo declined; objective Oura ring data showed significant improvements in deep sleep, REM sleep, & light sleep duration; mood, energy, alertness, & daily productivity were also improved.

Dose: 1500 mgDuration: 21 daysForm: L-threonate
Forms

Stacks containing Magnesium L-Threonate

Public community stacks that include this ingredient.

Explore all stacks →
sleeprecoverycalm

Combining Valerian with Magnesium L-Threonate can enhance sleep quality and promote recovery. Valerian is known for its calming effects, while Magnesium L-Threonate supports relaxation and cognitive recovery.

Valerian
500mg
Magnesium L-Threonate
1500mg
New
View