Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

LSD

LSD is a serotonin 2A agonist psychedelic being researched for its potential benefits in treating anxiety, depression, & cluster headaches, with early evidence suggesting it may promote neuroplasticity.

mental-healthanxietyneuroplasticitycognitive

Evidence last reviewed: 05 Apr 2026

Buy this ingredient ← Back

Supplement note

Private note on this supplement

Save how you reacted, what dose worked, what to watch for, or anything you want to remember later in your Notes tab.

Biomarkers studied

Outcomes directly measured across the evidence records below

Cognitive

Mood / WellbeingNeuroprotection / NGFAnxiety

Evidence

4 records

Mood disorder treatment

Patients with mood disorders • Meta-analysis

PUBMEDLow

LSD shows potential therapeutic effects on mood disorders, but more research is needed.

Dose: 0 mg

Citation: Yao et al. (2024). Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis. Psychiatry Research.

Limited number of well-designed clinical trials.

Depressive symptom reduction

Patients with treatment-resistant depression • Systematic review

PUBMEDLow

LSD may have therapeutic effects in reducing depressive symptoms, though evidence is preliminary.

Dose: 0 mg

Citation: Ko et al. (2023). Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis. Journal of Affective Disorders.

Research is observational & lacks robust clinical trials.

Neuroplasticity

General population • Systematic review

PUBMEDVery low

Preliminary evidence suggests LSD may promote neuroplasticity.

Dose: 0 mg

Citation: Reiff et al. (2020). Psychedelics and Psychedelic-Assisted Psychotherapy. American Journal of Psychiatry.

Evidence is largely theoretical & based on early-stage research.

Anxiety reduction

Patients with anxiety associated with life-threatening diseases • RCT

PUBMEDLow

LSD-assisted psychotherapy showed potential in reducing anxiety symptoms.

Dose: 0 mgDuration: Short-termForm: Oral

Citation: Gasser et al. (2014). Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. Frontiers in Psychology.

Small sample size & lack of long-term follow-up limit conclusions.

Forms

Oral

Typically administered in microgram doses for therapeutic use.

Blotter

Common form for recreational use, but also used in clinical settings.

Stacks containing LSD

Public community stacks that include this ingredient.

Explore all stacks →

No public stacks include this ingredient yet.