StackTerminal.Health

BETA

Lion's Mane

Medicinal mushroom; hericenones/erinacines may stimulate NGF. Evidence for cognition & mood is growing but still limited.

cognitionfocusgut-healthlongevity
Evidence last reviewed: 04 Apr 2026
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Trade-offs & context
Known concerns, timing considerations, & interactions
Allergy

Skin itching/hives rarely reported — possible immune modulation; discontinue if it occurs

Timing

Cognitive effects typically take 4–8 weeks to emerge; no meaningful acute effect

Dot colour: High concern  Moderate   Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Cognitive Function
Evidence
1 record
Cognitive function / mild cognitive impairment
Older adults; healthy young adultsRCTs + preclinical
PUBMEDModerate

Modest cognitive improvements in some trials; neurogenesis pathway plausible but clinical evidence still limited.

Dose: 1000 mgDuration: 8–16 weeks
Quality varies widely between products; look for fruiting-body standardisation.
Forms
Fruiting body extract
Higher bioactive content than mycelium-only products.
Dual extract (water + alcohol)
Extracts both polysaccharides and hericenones.

Stacks containing Lion's Mane

Public community stacks that include this ingredient.

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cognitiveneuroprotectionfocus

Combining Lion's Mane with Bacopa Monnieri can enhance cognitive function and provide neuroprotection. Lion's Mane promotes nerve growth factor production, while Bacopa supports memory and cognitive performance.

Lion's Mane
500mg
Bacopa Monnieri
300mg
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