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Lion's Mane Mushroom

Lion's Mane Mushroom is a medicinal mushroom that supports neurogenesis, memory, & mood, primarily benefiting cognitive function & neuroprotection.

cognitivememoryneuroprotectionfocus

Evidence last reviewed: 05 Apr 2026

Bottom line

Lion's Mane Mushroom is a supplement that may enhance cognitive function and memory. It shows potential for neuroprotection without documented risks.

Summarized study outcomes with population, design, grade, and effect data.

3 recordsBest grade:Moderate
Cognitive functionNeuroprotectionMemory

Moderate evidence suggests Lion's Mane Mushroom can improve cognitive function and memory, particularly in older adults with mild cognitive impairment. While the research is promising, more extensive studies are needed to confirm these benefits across broader populations.

Biomarkers studied
Cognitive
Cognitive FunctionMood / WellbeingNeuroprotection / NGFMemory
Cognitive function
Young adults · RCT
Moderate

Lion's Mane Mushroom shows promise in improving cognitive function & mood.

Dose: 1000 mg
Study focused on both acute & chronic effects.
Neuroprotection
General population · Systematic review
Moderate

Lion's Mane Mushroom may support neuroprotection through stimulation of nerve growth factor synthesis.

Dose: 1000 mgDuration: ChronicForm: Extract
Based on known bioactive compounds hericenones & erinacines.
Memory
Older adults with mild cognitive impairment · RCT
Moderate

Supplementation improved memory in older adults with mild cognitive impairment.

Dose: 1000 mgDuration: 16 weeksForm: CapsuleTiming: Daily
Memory improvements noted in older adults.

Stacks containing Lion's Mane Mushroom

Public community stacks that include this ingredient.

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cognitiveneuroplasticityfocus

Oxiracetam & lion's mane mushroom are combined to enhance cognitive function & neuroplasticity. Oxiracetam is known for its memory-enhancing effects, while lion's mane mushroom supports neurogenesis & cognitive performance.

Oxiracetam
800mg
Lion's Mane Mushroom
500mg
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