Lactobacillus acidophilus

Lactobacillus acidophilus is a probiotic strain that supports gut and vaginal health, with evidence for reducing IBS symptoms, preventing UTIs, and modulating cholesterol levels.

vaginal-healthgut-healthwomens-healthimmune-supportmetabolic-health

Evidence last reviewed: 20 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cognitive

Cognitive Function

Gut

Gut Microbiome

Evidence

4 records

Gut microbiota modulation

Children with antibiotic-associated diarrhea • RCT

PUBMEDModerate

Lactobacillus acidophilus reduced the overall risk of diarrhea during and after antibiotic treatment.

Dose: —

Citation: Sniffen et al. (2018). Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.

Cognitive function recovery

Patients with cerebral ischemia • RCT

PUBMEDLow

Lactobacillus acidophilus promoted cognitive function recovery by regulating microglial peroxisomal function.

Dose: —

Citation: Huang et al. (2025). Lactobacillus acidophilus promotes cognitive function recovery via regulating microglial peroxisomal function in cerebral ischemia.

Cholestatic liver injury amelioration

Patients with cholestatic liver injury • RCT

PUBMEDLow

Lactobacillus acidophilus ameliorated liver injury by inhibiting bile acid synthesis and promoting excretion.

Dose: —

Citation: Wu et al. (2024). Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.

Vaginal flora maintenance

Women with recurrent vulvovaginal candidiasis • RCT

PUBMEDModerate

Probiotics, including Lactobacillus acidophilus, were effective as maintenance treatment for recurrent vulvovaginal candidiasis.

Dose: —

Citation: Russo et al. (2019). Randomised clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment.

Forms

Capsule

Commonly used for oral supplementation.

Powder

Can be mixed with food or drinks.

Yogurt

Often found in probiotic-rich foods.

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