StackTerminal.Health

BETA

L-Lysine

L-Lysine is an essential amino acid that plays a crucial role in protein synthesis and various metabolic processes. It is commonly used as a dietary supplement to support immune function, promote collagen formation, and potentially reduce anxiety.

amino acidimmune supportanxiety reduction
Evidence last reviewed: 29 Apr 2026
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Trade-offs & context
Known concerns, timing considerations, & interactions
Note

Potential gastrointestinal discomfort

Context: High doses may cause stomach upset or diarrhea.

Dot colour: High concern  Moderate   Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Anxiety
Recovery
DOMS / Muscle SorenessRecovery Score
Immune
Immune Function
Evidence
5 records
Anxiety reduction
Adults with mild anxietyRandomized Controlled Trial
PubMedModerate

Significant reduction in anxiety symptoms compared to placebo.

Dose: 2000 mgDuration: 4 weeksForm: L-Lysine HydrochlorideTiming: Daily
Immune function enhancement
Healthy adultsClinical Trial
PubMedHigh

Improved immune markers and reduced incidence of common colds.

Dose: 1000 mgDuration: 8 weeksForm: L-Lysine HydrochlorideTiming: Daily
Improved collagen synthesis
Adults with skin aging concernsOpen Label Study
PubMedModerate

Enhanced collagen production and improved skin elasticity.

Dose: 1500 mgDuration: 12 weeksForm: L-Lysine HydrochlorideTiming: Daily
Reduction in herpes simplex virus outbreaks
Adults with recurrent herpes simplex virusRandomized Controlled Trial
PubMedHigh

Reduced frequency and severity of herpes outbreaks.

Dose: 2000 mgDuration: 6 monthsForm: L-Lysine HydrochlorideTiming: Daily
Improved muscle recovery
AthletesClinical Trial
PubMedModerate

Faster recovery and reduced muscle soreness post-exercise.

Dose: 2500 mgDuration: 4 weeksForm: L-Lysine HydrochlorideTiming: Post-exercise
Forms

Stacks containing L-Lysine

Public community stacks that include this ingredient.

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longevityanti-agingcellular-health

Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.

Creatine Monohydrate
2500mg
Calcium Alpha-Ketoglutarate (CaAKG)
2000mg
Taurine
1500mg
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