StackTerminal.Health

KPV

Tripeptide (α-MSH fragment) studied mainly in gut inflammation models; evidence is largely preclinical.

goal:gut-digestiongoal:gut-healthgoal:microbiomeconstraint:not-drug-test-safeevidence:lowstudy:mechanistic-animalpop:other-unclearform:other
Dosing model
FLATFixed dose (no body-weight scaling).
Min dose
—
Max dose
—
Rounding
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gutdigestionresearch-only

Research-only: Gut / Inflammation (KPV + BPC-157)

by@athlete

Groups gut-inflammation oriented peptides (mostly studied in preclinical colitis/inflammation models).

KPV
1mg
BPC-157
1mg
Magnesium (Glycinate)
400mg
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Evidence
3 records
Colitis severity reduction
Mouse colitis models + cellular models • Preclinical (cell + mouse)
Low

KPV showed anti-inflammatory effects mediated by PepT1 transport in intestinal epithelial/immune cells and reduced inflammation in mouse colitis models.

Dose: — • Duration: Preclinical protocol (see paper)
Citation: Dalmasso et al., Am J Physiol Gastrointest Liver Physiol (2008) — PepT1-mediated KPV uptake and colitis models
Colitis-associated cancer prevention (preclinical)
Mouse models (PepT1-expressing) • Preclinical (animal)
Low

KPV transported via PepT1 reduced colitis severity and prevented carcinogenesis in murine colitis-associated cancer models; no human trials identified.

Dose: —
Citation: Dalmasso et al., Inflamm Bowel Dis (2016) — Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of KPV
Targeted KPV delivery for ulcerative colitis (preclinical)
Mouse ulcerative colitis models (DSS and TNBS) • Preclinical (animal + in vitro)
Low

Hyaluronic acid-functionalized nanoparticles loaded with KPV showed targeted delivery to colonic epithelial cells and macrophages, reducing inflammation in murine UC models; translational relevance to humans is not established.

Dose: —
Citation: Xiao et al., Mol Ther (2017) — Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles
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Research material (vendor listing)