StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Ketamine

Ketamine is an NMDA receptor antagonist known for its rapid-onset antidepressant effects, particularly in treatment-resistant depression, with response observed within hours.

mental-healthdepressionneuroplasticityanalgesia
Evidence last reviewed: 05 Apr 2026
Supplement note
Private note on this supplement

Save how you reacted, what dose worked, what to watch for, or anything you want to remember later in your Notes tab.

Sign in to keep a private note on Ketamine.
Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
Blood Pressure
Cognitive
Mood / Wellbeing
Evidence
5 records
Treatment-resistant depression
Adults with major depressive disorderSystematic review
PUBMEDHigh

Ketamine shows significant efficacy in reducing symptoms of treatment-resistant depression.

Dose: 500 mg
Real-world effectiveness
Patients with treatment-resistant depressionSystematic review
PUBMEDModerate

Real-world data supports ketamine's effectiveness in treatment-resistant depression.

Dose: 500 mg
Side effects
Patients using ketamine for depressionSystematic review
PUBMEDModerate

Ketamine use is associated with side effects such as dissociation & increased blood pressure.

Dose: 500 mg
Depression severity
Patients with major depressive episodeSystematic review
PUBMEDModerate

Ketamine is effective in reducing depression severity compared to electroconvulsive therapy.

Dose: 500 mg
Chronic pain
Adults with chronic painSystematic review
PUBMEDModerate

Ketamine infusions are associated with pain relief in chronic pain conditions.

Dose: 500 mg
Forms
Intravenous
Commonly used in clinical settings for rapid antidepressant effects.
Intranasal
Esketamine form approved for treatment-resistant depression.
Oral
Less common, used in some studies for depression.

Stacks containing Ketamine

Public community stacks that include this ingredient.

Explore all stacks →
No public stacks include this ingredient yet.