Myo-Inositol
Insulin sensitiser with strong evidence in PCOS; also studied for OCD, panic disorder, & fertility.
Evidence last reviewed: 04 Apr 2026
Myo-Inositol is an insulin sensitizer with strong evidence for improving symptoms of PCOS. It may also help with anxiety disorders but can cause gastrointestinal discomfort.
GI discomfort (loose stools, bloating) — spread across the day rather than taking a single large dose
Context: single doses >4g
May lower blood glucose — caution if on diabetes medications (metformin, insulin, SGLT2 inhibitors)
Drowsiness at higher doses — take in the evenings if this occurs
Summarized study outcomes with population, design, grade, and effect data.
Myo-Inositol has high-quality evidence supporting its effectiveness in improving insulin resistance and hormonal markers in women with PCOS. While it shows promise for other conditions like OCD, more research is needed to establish its efficacy in those areas.
Insulin sensitivity / hormonal markers in PCOSWomen with PCOS · Meta-analyses of RCTsHigh
Reliably improves insulin resistance, androgen levels, & menstrual regularity in PCOS; comparable to metformin in some studies.
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