Myo-Inositol
Insulin sensitiser with strong evidence in PCOS; also studied for OCD, panic disorder, & fertility.
womens-healthmetabolichormonesstress
Evidence last reviewed: 04 Apr 2026
Trade-offs & context
Known concerns, timing considerations, & interactions
Tolerance
GI discomfort (loose stools, bloating) — spread across the day rather than taking a single large dose
Context: single doses >4g
Interaction
May lower blood glucose — caution if on diabetes medications (metformin, insulin, SGLT2 inhibitors)
Timing
Drowsiness at higher doses — take in the evenings if this occurs
Dot colour: ●High concern ●Moderate ● Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Metabolic
Insulin Sensitivity
Evidence
1 record
Insulin sensitivity / hormonal markers in PCOS
Women with PCOS • Meta-analyses of RCTs
PUBMEDHigh
Reliably improves insulin resistance, androgen levels, & menstrual regularity in PCOS; comparable to metformin in some studies.
Dose: 4000 mgDuration: 12–24 weeks
Also studied for fertility outcomes; generally very well tolerated.
Forms
Myo-inositol powder
Most studied form; highly soluble.
Myo-inositol + D-chiro-inositol (40:1)
Preferred ratio in PCOS protocols.
Stacks containing Myo-Inositol
Public community stacks that include this ingredient.
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My Sample Stack
by@tin_man140_6
Built from your selected goals, constraints, diet, & the supplement evidence library. You can edit doses & timing.
Vitamin B-Complex
26mg
Vitamin C
500mg
Ashwagandha
600mg
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