HMB (Beta-Hydroxy Beta-Methylbutyrate)
HMB is a metabolite of the branched-chain amino acid leucine that inhibits muscle protein breakdown via the ubiquitin-proteasome pathway; evidence supports modest preservation of lean mass & strength, particularly in older adults & catabolic states.
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Meta-analysis of 15 RCTs (n=2,137) found HMB-containing supplements increased muscle mass & showed strong evidence for improving muscle strength; effect sizes were modest & further high-quality studies were recommended.
Meta-analysis of 21 RCTs (n=1,935) found HMB supplementation at 3 g/day for >12 weeks increased appendicular skeletal muscle mass by 1.56 kg, lean mass by 0.28 kg, handgrip strength by 0.54 kg, & improved gait speed & chair-stand performance.
Stacks containing HMB (Beta-Hydroxy Beta-Methylbutyrate)
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