StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Guanfacine

Guanfacine is a selective alpha-2A agonist used primarily for treating ADHD in children & adults, improving prefrontal cortex function, working memory, & impulse control.

adhdfocuscognitiveanxiety
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Focus / AttentionCognitive Function
Evidence
5 records
ADHD symptom reduction
Children, adolescents, and adults with ADHDSystematic review
PUBMEDHigh

Guanfacine was found to be effective in reducing ADHD symptoms compared to placebo.

Dose: 2 mg
ADHD symptom reduction
Children and adolescents with ADHDSystematic review
PUBMEDModerate

Guanfacine was effective in reducing ADHD symptoms in children & adolescents.

Dose: 2 mg
ADHD symptom reduction
Adults with ADHDSystematic review
PUBMEDModerate

Guanfacine showed efficacy in reducing ADHD symptoms in adults.

Dose: 2 mg
ADHD symptom reduction
Adults with ADHDSystematic review
PUBMEDLow

Guanfacine was included in the analysis of ADHD treatments, showing efficacy in symptom reduction.

Dose: 2 mg
ADHD symptom reduction
Children and adolescents with ADHDSystematic review
PUBMEDModerate

Guanfacine was effective in reducing ADHD symptoms in children & adolescents.

Dose: 2 mg
Forms
Immediate-release
Typically used for hypertension but can be used off-label for ADHD.
Extended-release
Specifically formulated for ADHD treatment, allowing once-daily dosing.

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