Glutathione (Reduced)
Master antioxidant; oral bioavailability historically questioned but liposomal forms show better absorption.
Evidence last reviewed: 04 Apr 2026
Glutathione is a powerful antioxidant, but its standard oral form has poor absorption. Liposomal or S-acetyl forms are more effective for boosting levels in the body.
Standard oral reduced glutathione has poor bioavailability — liposomal or S-acetyl form required for meaningful absorption
High-dose antioxidant supplementation may blunt exercise-induced ROS signalling, potentially reducing training adaptations
Context: doses >500mg/day during high-volume training
Summarized study outcomes with population, design, grade, and effect data.
Research indicates that liposomal and S-acetyl glutathione can significantly increase blood levels of glutathione and improve oxidative stress markers. However, studies are limited in size and scope, necessitating further investigation into long-term effects and optimal dosing.
Oxidative stress markers / immune functionHealthy adults; older adults · RCTs (small)Moderate
Liposomal & S-acetyl forms show meaningful increases in blood GSH; oxidative stress markers improve.
Stacks containing Glutathione (Reduced)
Public community stacks that include this ingredient.
Longevity Mix (Bryan Johnson)
Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.