Glutathione (Reduced)
Master antioxidant; oral bioavailability historically questioned but liposomal forms show better absorption.
longevityantioxidantimmunedaily
Evidence last reviewed: 04 Apr 2026
Trade-offs & context
Known concerns, timing considerations, & interactions
Tolerance
Standard oral reduced glutathione has poor bioavailability — liposomal or S-acetyl form required for meaningful absorption
Note
High-dose antioxidant supplementation may blunt exercise-induced ROS signalling, potentially reducing training adaptations
Context: doses >500mg/day during high-volume training
Dot colour: ●High concern ●Moderate ● Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Inflammation
Oxidative Stress (MDA)
Immune
Immune Function
Evidence
1 record
Oxidative stress markers / immune function
Healthy adults; older adults • RCTs (small)
PUBMEDModerate
Liposomal & S-acetyl forms show meaningful increases in blood GSH; oxidative stress markers improve.
Dose: 500 mgDuration: 4–12 weeks
Citation: Richie et al. 2015; Schmitt et al. 2015
NAC is a cheaper alternative that reliably raises glutathione.
Forms
Liposomal glutathione
Best oral bioavailability.
S-acetyl glutathione
More stable than standard GSH.
NAC (precursor)
Raises glutathione indirectly — often preferred.
Stacks containing Glutathione (Reduced)
Public community stacks that include this ingredient.
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