StackTerminal.Health

Glutamine

Glutamine is the most abundant amino acid in the body and the primary fuel for enterocytes and immune cells; evidence supports its role in preserving gut barrier integrity under stress and dramatically reducing symptoms in post-infectious irritable bowel syndrome.

gut-healthimmunerecoverymucosal-integritysports
Dosing model
FLATFixed dose (no body-weight scaling).
Min dose
5000 mg
Max dose
10000 mg
Rounding
500 mg
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Evidence
2 records
Post-infectious irritable bowel syndrome (IBS-D) symptom severity
Adults with diarrhea-predominant post-infectious IBS • RCT
Moderate

A randomized placebo-controlled trial (n=106) found 79.6% of the glutamine group versus 5.8% of placebo achieved the primary endpoint (≥50-point reduction in IBS Severity Scoring System), a 14-fold difference; glutamine also reduced bowel movement frequency and improved intestinal permeability measures.

Dose: 10000 mg • Duration: 8 weeks
Citation: Zhou Q, Verne ML, Fields JZ, et al. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2019;68(6):996-1002.
Intestinal permeability in adults
Mixed adult populations (athletes, surgical, critical illness) • systematic review and meta-analysis of RCTs
Low

Meta-analysis of 10 clinical trials (n=352) found that overall glutamine supplementation did not significantly reduce intestinal permeability, but subgroup analysis showed significant benefit at doses >30 g/day for durations under 2 weeks, suggesting dose-dependent effects.

Dose: 10000 mg • Duration: variable
Citation: Abbasi F, Haghighat Lari MM, Khosravi GR, et al. A systematic review and meta-analysis of clinical trials on the effects of glutamine supplementation on gut permeability in adults. Amino Acids. 2024;56(1):71.
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