Glucosamine
Amino sugar supporting cartilage synthesis; most evidence for knee osteoarthritis pain, especially glucosamine sulfate.
jointcartilageinflammationlongevity
Evidence last reviewed: 04 Apr 2026
Trade-offs & context
Known concerns, timing considerations, & interactions
Allergy
Derived from shellfish — contraindicated in shellfish allergy; plant-derived (corn) glucosamine is the allergen-free alternative
Interaction
May raise fasting blood glucose slightly — monitor if diabetic or pre-diabetic
Interaction
Mild anticoagulant activity — caution with warfarin
Dot colour: ●High concern ●Moderate ● Low / note
Evidence
1 record
Knee osteoarthritis pain / joint function
Adults with knee OA • Meta-analyses (mixed quality)
COCHRANEModerate
Modest pain reduction in OA; glucosamine sulfate shows stronger effects than HCl; often combined with chondroitin.
Dose: 1500 mgDuration: 8–24 weeksForm: Sulfate
Often combined with chondroitin & MSM for joint stacks.
Forms
Glucosamine sulfate
Most studied form; prescription in some countries.
Glucosamine HCl
Common OTC form; possibly slightly less effective.
Stacks containing Glucosamine
Public community stacks that include this ingredient.
jointrecoverylongevity
Joint Health & Recovery
by@athlete
Glucosamine & MSM are combined to support joint health & recovery. Glucosamine aids in cartilage repair & reduces joint pain, while MSM provides anti-inflammatory support & enhances joint flexibility.
Glucosamine
1500mg
MSM (Methylsulfonylmethane)
3000mg
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