Fisetin

Fisetin is a flavonoid with senolytic properties that helps clear senescent cells, potentially aiding in longevity & reducing age-related biomarkers in the elderly.

longevityanti-agingantioxidantanti-inflammatory

Evidence last reviewed: 05 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cognitive

Neuroprotection / NGF

Inflammation

Oxidative Stress (MDA)

Immune

Immune Function

Evidence

4 records

Senolytic activity

Older individuals • Systematic review

PUBMEDLow

Senotherapy, including fisetin, may eliminate senescent cells & reduce aging-associated disability & diseases.

Dose: 1000 mg

Citation: Balducci et al. (2024). Senotherapy, cancer, and aging. Journal of Geriatric Oncology.

Antioxidant activity

General population • Systematic review

PUBMEDLow

Fisetin reduces reactive oxygen species & upregulates antioxidant enzymes, potentially attenuating oxidative stress.

Dose: 1000 mg

Citation: Prem et al. (2022). Recent advances in potential of Fisetin in the management of myocardial ischemia-reperfusion injury-A systematic review. Reviews in Cardiovascular Medicine.

Neuroprotection

Individuals with neurological diseases • Systematic review

PUBMEDLow

Fisetin may offer neuroprotective benefits through its antioxidant & anti-inflammatory properties.

Dose: 1000 mg

Citation: Jiang et al. (2023). The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review.

Cancer prevention

Individuals at risk of cancer • Systematic review

PUBMEDLow

Fisetin, as part of senotherapy, may decrease cancer incidence & improve treatment tolerance.

Dose: 1000 mg

Citation: Wendlocha et al. (2023). Selected Flavonols in Breast and Gynecological Cancer: A Systematic Review.

Forms

Capsule

Commonly available in capsule form for oral consumption.

Powder

Can be mixed with liquids or foods for easier ingestion.

Stacks containing Fisetin

Public community stacks that include this ingredient.

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metabolicantioxidantlongevity

Metabolic & Antioxidant Support

by@athlete

Alpha-lipoic acid & fisetin are combined to support metabolic health & provide antioxidant benefits. Alpha-lipoic acid improves insulin sensitivity & supports metabolic function, while fisetin offers anti-aging & antioxidant support.

Alpha-Lipoic Acid (ALA)

600mg

Fisetin

1000mg

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