StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

DSIP (Delta Sleep-Inducing Peptide)

DSIP is a peptide that may help improve sleep quality and reduce sleep latency, with potential effects on cortisol modulation, though evidence is limited.

sleeprecoverystresscortisol
Evidence last reviewed: 19 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Sleep
Sleep Quality (subjective)Sleep Latency
Hormonal
Cortisol
Evidence
3 records
Sleep normalization
Patients with severe insomnia • Case series
PUBMEDLow

Sleep was normalized in all but one case, with improved mood and daytime performance.

Dose: 0 mgDuration: 3-7 months follow-upForm: Injection
Citation: Kaeser et al. (1984). A clinical trial with DSIP. Journal.
Open study with a small sample size.
Reduction of ACTH
Healthy male volunteers • RCT
PUBMEDModerate

Significant reduction of ACTH-like immunoreactivity in plasma for at least 3 hours after DSIP injection.

Dose: 0 mgDuration: 3 hoursForm: Injection
Citation: Bjartell et al. (1989). Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man. Journal.
Cortisol levels were unaffected.
Opioid detoxification
Patients undergoing opioid detoxification • Case series
PUBMEDVery low

DSIP was used in an open clinical trial for opioid detoxification.

Dose: 0 mgForm: Injection
Citation: Backmund et al. (1998). Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trial. Journal.
No abstract available.
Forms
Injection
Typically administered via intravenous injection in clinical settings.

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