StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

DMT

DMT is an endogenous tryptamine & serotonin 2A agonist that may reduce depression & anxiety & promote neuroplasticity.

mental-healthanxietyneuroplasticity
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Mood / WellbeingAnxietyNeuroprotection / NGF
Evidence
3 records
Mood improvement
Individuals with mood disorders • Systematic review
PUBMEDModerate

Psychedelics, including DMT, have shown potential in improving mood disorders.

Dose: 20 mgForm: Ayahuasca
Citation: Hinkle et al. (2024). Adverse Events in Studies of Classic Psychedelics: A Systematic Review and Meta-Analysis. Journal.
Ayahuasca was specifically noted for its mood-improving effects.
Depression & anxiety reduction
Individuals with treatment-resistant depression • Systematic review and Meta-analysis
PUBMEDModerate

Psychedelics, including DMT, show therapeutic effects on depression & anxiety.

Dose: 20 mgForm: Ayahuasca
Citation: Hinkle et al. (2024). Adverse Events in Studies of Classic Psychedelics: A Systematic Review and Meta-Analysis. Journal.
Ayahuasca, which contains DMT, was specifically noted for its effects.
Neuroplasticity
General population • Narrative review
PUBMEDLow

DMT & other psychedelics may promote neuroplasticity, though more research is needed.

Dose: 20 mg
Citation: Ho et al. (2020). Psychophysiological Effects of Dance Movement Therapy and Physical Exercise on Older Adults With Mild Dementia: A Randomized Controlled Trial. Journal.
The review included DMT among other psychedelics.
Forms
Ayahuasca
Traditional brew containing DMT, often used in ceremonial contexts.
Synthetic DMT
Pure form, typically vaporized or injected for rapid onset.

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