StackTerminal.Health

BETA

DIM (Diindolylmethane)

DIM is a supplement derived from cruciferous vegetables that modulates estrogen metabolism & may support hormonal balance, prostate health, & weight management.

hormonalanti-cancerprostate-healthbody-composition
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Hormonal
Estrogen
Metabolic
Body Fat %
Evidence
4 records
Breast cancer biomarker modulation
Patients taking tamoxifen • RCT
PUBMEDLow

DIM showed potential in modulating breast cancer biomarkers, although further research is needed to confirm clinical benefits.

Dose: 200 mgForm: BioResponse DIM
Citation: Thomson et al. (2017). A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Research and Treatment.
Body fat reduction
Premenopausal women • RCT
PUBMEDModerate

DIM supplementation favored benign estrogen metabolism pathways & was associated with decreased body fat.

Dose: 200 mg
Citation: Godínez-Martínez et al. (2023). Effectiveness of 3,3'-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Body Fat in Premenopausal Women.
Prostate cancer biomarkers
Patients with prostate cancer undergoing prostatectomy • RCT
PUBMEDModerate

BR-DIM was associated with modulation of prostate cancer biomarkers, suggesting potential therapeutic benefits.

Dose: 200 mgForm: BioResponse DIM
Citation: Gee et al. (2016). Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy.
Estrogen metabolism
Women taking tamoxifen • RCT
PUBMEDModerate

BR-DIM increased the 2/16α-hydroxyestrone ratio & serum SHBG levels, indicating favorable changes in estrogen metabolism.

Dose: 300 mgDuration: 12 monthsForm: BioResponse DIM
Citation: Higdon et al. (2007). Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Oncotarget.
Forms
BioResponse DIM
Enhanced bioavailability form commonly used in studies.
Standard DIM
Less bioavailable form, often requiring higher doses.

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