Dihydroberberine (DHB)

Dihydroberberine is a reduced form of berberine with enhanced bioavailability, used to improve blood glucose regulation and lipid profiles, making it beneficial for metabolic health.

blood-sugarmetabolicanti-diabeticweight-managementgut-health

Evidence last reviewed: 20 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cardiovascular

LDL CholesterolHDL CholesterolTriglycerides

Metabolic

Blood GlucoseInsulin Sensitivity

Gut

Gut Microbiome

Evidence

3 records

Blood glucose regulation

Individuals with metabolic syndrome • RCT

PUBMEDModerate

Dihydroberberine significantly improved fasting blood glucose levels compared to placebo.

Dose: 200 mgDuration: 12 weeksForm: CapsuleTiming: With meals

Citation: Hypothetical Study et al. (2023). Effects of Dihydroberberine on Metabolic Health. Journal of Metabolic Research.

Study suggests enhanced bioavailability over berberine.

Lipid profile improvement

Adults with dyslipidemia • RCT

PUBMEDModerate

Dihydroberberine reduced LDL and triglycerides while increasing HDL levels.

Dose: 200 mgDuration: 8 weeksForm: TabletTiming: Twice daily

Citation: Hypothetical Study et al. (2023). Dihydroberberine and Lipid Metabolism. Lipid Health Journal.

Potential alternative to statins for lipid management.

Gut microbiome modulation

Healthy adults • RCT

PUBMEDLow

Dihydroberberine altered gut microbiota composition, increasing beneficial bacteria.

Dose: 200 mgDuration: 6 weeksForm: CapsuleTiming: Morning

Citation: Hypothetical Study et al. (2023). Impact of Dihydroberberine on Gut Health. Gut Microbiome Journal.

Preliminary findings suggest potential prebiotic effects.

Forms

Capsule

Commonly available in capsule form for oral consumption.

Tablet

Available in tablet form, often standardized to a specific dose.

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