D-Ribose

D-Ribose is a pentose sugar that plays a crucial role in ATP & nucleotide synthesis, showing potential benefits for individuals with chronic fatigue syndrome, fibromyalgia, cardiac energy depletion, & those needing exercise recovery.

energyrecoverycardiovascularmitochondrial

Evidence last reviewed: 05 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cognitive

Cognitive Function

Performance

Power Output

Evidence

4 records

mental fatigue

healthy adults • RCT

PUBMEDLow

D-Ribose, in combination with caffeine, was studied for its effects on mental fatigue.

Dose: 5000 mg

Citation: Ataka et al. (2008). Effects of oral administration of caffeine and D-ribose on mental fatigue.

anaerobic capacity

healthy males • RCT

PUBMEDLow

D-Ribose supplementation was evaluated for its effects on anaerobic capacity & metabolic markers.

Dose: 5000 mg

Citation: Kreider et al. (2003). Effects of oral D-ribose supplementation on anaerobic capacity and selected metabolic markers in healthy males.

quality of life

congestive heart failure patients • Case series

PUBMEDLow

D-Ribose improved diastolic function & quality of life in congestive heart failure patients.

Dose: 5000 mg

Citation: Omran et al. (2003). D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study.

cardiac performance

patients with heart failure with preserved ejection fraction • RCT

PUBMEDModerate

D-Ribose supplementation showed potential to reduce symptoms & improve cardiac performance.

Dose: 5000 mgDuration: 12 weeks

Citation: Pierce et al. (2022). Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction. American Journal of Cardiology.

Forms

Powder

Commonly used for mixing with water or other beverages.

Capsule

Convenient for precise dosing.

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