StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Cymbalta (Duloxetine)

Cymbalta is an SNRI used to treat depression, anxiety, fibromyalgia, & diabetic neuropathy, offering benefits for both mood & pain management through central sensitization pathways.

mental-healthdepressionpainanxiety
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Mood / Wellbeing
Evidence
4 records
Fibromyalgia symptom improvement
Adults with fibromyalgiaSystematic review and meta-analysis
PUBMEDHigh

Duloxetine was more effective than placebo in managing fibromyalgia symptoms.

Dose: 60 mg
Major depressive disorder relapse prevention
Adults with major depressive disorderSystematic review and network meta-analysis
PUBMEDHigh

Duloxetine was effective in preventing relapse in the maintenance phase of major depressive disorder.

Dose: 60 mgDuration: 6 months
Chemotherapy-induced peripheral neuropathy symptom management
Patients with chemotherapy-induced peripheral neuropathySystematic review and meta-analysis
PUBMEDHigh

Duloxetine was effective in improving symptoms of chemotherapy-induced peripheral neuropathy.

Dose: 60 mg
Withdrawal symptoms upon discontinuation
Patients discontinuing SNRI treatmentSystematic review
PUBMEDModerate

Withdrawal symptoms were common after discontinuation of SNRIs, including duloxetine.

Dose: 60 mg
Forms
Capsule
Commonly available in 20 mg, 30 mg, and 60 mg doses.

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