StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Clonidine

Clonidine is a central alpha-2 agonist used primarily for hypertension & ADHD, with evidence supporting its use in reducing anxiety, PTSD symptoms, opioid withdrawal, & tic disorders.

cardiovascularadhdanxietysleep
Evidence last reviewed: 05 Apr 2026
Supplement note
Private note on this supplement

Save how you reacted, what dose worked, what to watch for, or anything you want to remember later in your Notes tab.

Sign in to keep a private note on Clonidine.
Biomarkers studied
Outcomes directly measured across the evidence records below
Sleep
Sleep Quality (subjective)Sleep Duration
Cognitive
Mood / Wellbeing
Evidence
4 records
Sedation quality
Critically ill patientsSystematic review and meta-analysis
PUBMEDModerate

Clonidine was not superior to propofol in reducing time to successful extubation.

Dose: 0 mg
Opioid withdrawal symptoms
Neonates with opioid withdrawal syndromeRandomized Trial
PUBMEDModerate

Clonidine as monotherapy was effective for neonatal opioid withdrawal syndrome.

Dose: 0 mg
PTSD symptom severity
Adults with PTSDSystematic review
PUBMEDLow

Clonidine shows promise in improving sleep, nightmares, & PTSD symptoms, but further research is needed.

Dose: 0 mg
Oppositional behavior & aggression
Children and adolescents with ADHD, ODD, and conduct disorderSystematic review and meta-analysis
PUBMEDModerate

Alpha-2 agonists like clonidine are effective in managing oppositional behavior & aggression.

Dose: 0 mg
Forms
Tablet
Commonly used for hypertension and ADHD.
Patch
Used for continuous delivery in hypertension.
Injection
Used in clinical settings for rapid effects.

Stacks containing Clonidine

Public community stacks that include this ingredient.

Explore all stacks →
No public stacks include this ingredient yet.