StackTerminal.Health

BETA

Conjugated Linoleic Acid (CLA)

Conjugated Linoleic Acid (CLA) is a naturally occurring trans fatty acid found in ruminant fats, known for modestly reducing body fat and preserving lean mass, particularly in overweight individuals.

fat-lossbody-compositionweight-managementmetabolic
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Metabolic
Body Fat %Body Weight
Inflammation
TNF-αIL-6Oxidative Stress (MDA)
Immune
Immune Function
Evidence
4 records
Immune function modulation
Animal models and human studiesRCT
PUBMEDLow

CLA modulates immune function, affecting both innate and adaptive immune responses.

Dose: 3400 mg
Body fat reduction
Overweight and obese individualsSystematic review and meta-analysis
PUBMEDModerate

CLA supplementation resulted in a modest reduction in body fat over 12 weeks.

Dose: 3400 mgDuration: 12 weeks
Leptin concentration
General populationSystematic review and meta-analysis
PUBMEDModerate

CLA supplementation did not significantly change leptin levels overall, but reductions were noted in males and overweight individuals.

Dose: 3400 mg
Oxidative stress markers
General populationSystematic review and meta-analysis
PUBMEDModerate

CLA supplementation reduced oxidative stress markers, though results were not consistent across all studies.

Dose: 3400 mg
Forms
Capsule
Commonly used for standardized dosing.
Softgel
Preferred for ease of swallowing.
Powder
Can be mixed with liquids for flexible dosing.

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