Cissus Quadrangularis

Cissus Quadrangularis is an Ayurvedic herb known for its potential to accelerate bone fracture healing, reduce joint pain, and aid in weight management. It is commonly used by athletes for tendon and ligament support.

bone-healthjoint-healthweight-lossanti-inflammatory

Evidence last reviewed: 20 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cardiovascular

TriglyceridesLDL Cholesterol

Metabolic

Body Weight

Evidence

5 records

Bone pain reduction

General population with bone pain • Meta-analysis

PUBMEDModerate

Cissus quadrangularis showed significant effects on reducing bone pain.

Dose: 1500 mg

Citation: Sawangjit et al. (2017). Efficacy and Safety of Cissus quadrangularis L. in Clinical Use: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Journal.

Bone density improvement

Aging populations prone to bone disorders • Systematic review

PUBMEDModerate

Cissus quadrangularis is recognized for its potential benefits in promoting bone health, including bone density improvement.

Dose: 1500 mg

Citation: Na Takuathung et al. (2025). The effects of Cissus quadrangularis on bone-related biomarkers in humans: a systematic review and meta-analysis. Journal.

Weight loss

Individuals with metabolic syndrome • RCT

PUBMEDModerate

Cissus quadrangularis was associated with weight loss and metabolic improvements.

Dose: 1500 mg

Citation: Oben et al. (2006). The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Journal.

Osteogenic potential

Patients with intrabony defects • Exploratory clinical trial

PUBMEDLow

Cissus quadrangularis administration was associated with increased osteogenic potential.

Dose: 1500 mg

Citation: Jain et al. (2008). Modulatory effects of Cissus quadrangularis on periodontal regeneration by bovine-derived hydroxyapatite in intrabony defects: exploratory clinical trial. Journal.

Bone formation and maturation

Patients undergoing alveolar distraction • RCT

PUBMEDModerate

Cissus quadrangularis enhanced bone formation and maturation in the distracted area.

Dose: 1500 mg

Citation: Benjawan et al. (2022). The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Journal.

Forms

Capsule

Commonly used for ease of dosing.

Powder

Can be mixed with liquids or smoothies.

Extract

Concentrated form for higher potency.

Stacks containing Cissus Quadrangularis

Public community stacks that include this ingredient.

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joint-healthpainanti-inflammatory

Joint Health and Pain Relief

by@athlete

Combining Cissus Quadrangularis with Devil's Claw can support joint health and provide pain relief. Cissus Quadrangularis supports bone and joint health, while Devil's Claw is known for its anti-inflammatory and analgesic properties.

Cissus Quadrangularis

1500mg

Devil's Claw

2400mg

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