StackTerminal.Health

BETA

Casein Protein

Casein protein is a slow-digesting milk protein that releases amino acids over several hours, making it effective for reducing overnight muscle protein breakdown. It is particularly beneficial for athletes and individuals engaging in resistance training when taken before sleep.

muscle-growthrecoverysleepnutritional
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Performance
Power OutputMuscle Strength (1RM)Muscle Endurance
Recovery
Recovery Score
Evidence
4 records
Anaerobic power and strength
Soccer playersRCT
PUBMEDModerate

Pre-sleep casein ingestion with probiotics improved anaerobic power and lower-body-specific strength and power performance.

Dose: 30000 mgDuration: Not specifiedTiming: Before sleep
Combined with probiotics for enhanced effect.
Functional recovery
Professional soccer playersRCT
PUBMEDModerate

Presleep casein protein ingestion accelerated functional recovery in professional soccer players.

Dose: 30000 mgDuration: Not specifiedTiming: Before sleep
Post-prandial amino acid response
Healthy young menRCT
PUBMEDModerate

Different forms of casein protein modulated post-prandial plasma amino acid responses.

Dose: 40000 mgDuration: Single sessionForm: Micellar CaseinTiming: Post-exercise
Compared micellar, calcium, and sodium caseinate.
Overnight muscle protein synthesis
Healthy young menRCT
PUBMEDHigh

Casein protein ingestion prior to sleep increased myofibrillar protein synthesis rates during overnight recovery.

Dose: 45000 mgDuration: Single nightForm: Micellar CaseinTiming: 30 min before sleep
Forms
Micellar Casein
Slow-digesting form, ideal for pre-sleep consumption.
Calcium Caseinate
More soluble form, often used in protein blends.
Sodium Caseinate
Used in food processing, less common as a supplement.

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