StackTerminal.Health

BETA

Calcium Alpha-Ketoglutarate (CaAKG)

Calcium Alpha-Ketoglutarate (CaAKG) is a supplement studied for its potential geroprotective properties, aiming to reduce biological age and improve healthspan. It is being investigated for its effects on DNA methylation age, inflammatory markers, and metabolic parameters in middle-aged adults.

geroprotectoranti-aginghealthspan
Evidence last reviewed: 29 Apr 2026
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Known concerns, timing considerations, & interactions
Note

Potential reduction in biological age

Context: May reduce DNA methylation age in biologically older individuals.

Dot colour: High concern  Moderate   Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
HDL CholesterolLDL CholesterolTriglycerides
Metabolic
Blood Glucose
Performance
Muscle Strength (1RM)
Inflammation
IL-6TNF-αCRP (Inflammation)
Evidence
4 records
Reduction in DNA methylation age
Middle-aged adults with higher DNA methylation ageRandomized Controlled Trial
PubMedModerate

Potential reduction in biological age as measured by DNA methylation.

Dose: 1000 mgDuration: 6 monthsForm: Sustained Release
Study includes a 3-month follow-up period.
Improvement in inflammatory markers
Middle-aged adults with higher DNA methylation ageRandomized Controlled Trial
PubMedLow

Potential improvement in inflammatory markers.

Dose: 1000 mgDuration: 6 monthsForm: Sustained Release
Improvement in metabolic parameters
Middle-aged adults with higher DNA methylation ageRandomized Controlled Trial
PubMedLow

Potential improvement in metabolic health.

Dose: 1000 mgDuration: 6 monthsForm: Sustained Release
Improvement in muscle strength
Middle-aged adults with higher DNA methylation ageRandomized Controlled Trial
PubMedLow

Potential improvement in handgrip and leg extension strength.

Dose: 1000 mgDuration: 6 monthsForm: Sustained Release
Forms

Stacks containing Calcium Alpha-Ketoglutarate (CaAKG)

Public community stacks that include this ingredient.

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longevityanti-agingcellular-health

Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.

Creatine Monohydrate
2500mg
Calcium Alpha-Ketoglutarate (CaAKG)
2000mg
Taurine
1500mg
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