StackTerminal.Health

BETA

Butterbur (Petasites hybridus)

Butterbur is an herbal extract used primarily for migraine prevention and treatment of allergic rhinitis. It is important to use PA-free extracts to avoid potential liver toxicity.

painanti-inflammatoryrespiratoryneurological
Evidence last reviewed: 20 Apr 2026
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Evidence
5 records
Allergic rhinitis treatment
Adults with allergic rhinitisRCT
PUBMEDModerate

Petasites extract showed superiority over placebo for rhinosinusitis and allergic rhinitis.

Dose: 150 mgDuration: 12 weeksForm: PA-free extract
Allergic rhinitis treatment
Adults with allergic rhinitisRCT
PUBMEDModerate

Petasites extract was effective in reducing symptoms of allergic rhinitis compared to placebo.

Dose: 150 mgDuration: 12 weeksForm: PA-free extract
Migraine prevention
Adults with migraineRCT
PUBMEDHigh

Petasites extract significantly reduced migraine attack frequency compared to placebo.

Dose: 150 mgDuration: 4 monthsForm: PA-free extract
Migraine prevention
Adults with migraineRCT
PUBMEDHigh

Petasites extract 75 mg bid was more effective than placebo and well tolerated.

Dose: 150 mgDuration: 4 monthsForm: PA-free extract
Migraine prevention
Adults with migraineRCT
PUBMEDHigh

Petasites extract 75 mg bid reduced migraine frequency by 48% compared to placebo.

Dose: 150 mgDuration: 4 monthsForm: PA-free extract
Mild gastrointestinal events were reported.
Forms
PA-free extract
Standardized to contain petasin and isopetasin, free of pyrrolizidine alkaloids to avoid hepatotoxicity.

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