StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Buprenorphine

Buprenorphine is a partial opioid agonist used primarily for opioid use disorder treatment & pain management, offering a safer profile compared to full agonist opioids.

addictionpainmental-health
Evidence last reviewed: 05 Apr 2026
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Evidence
5 records
Pain management
Adults with acute postoperative painSystematic review and meta-analysis
PUBMEDHigh

Buprenorphine provides effective analgesia with a superior safety profile compared to full agonist opioids.

Dose: 16 mg
Opioid use disorder treatment
Adults with opioid dependenceSystematic review and meta-analysis
PUBMEDHigh

Buprenorphine is effective in reducing illicit opioid use & improving treatment retention compared to methadone.

Dose: 16 mg
Mortality risk reduction
People with opioid dependenceSystematic review and meta-analysis
PUBMEDHigh

Buprenorphine significantly reduces mortality risk during opioid substitution treatment.

Dose: 16 mg
Treatment retention
Adults with opioid use disorderRandomized Clinical Trial
PUBMEDModerate

Buprenorphine shows good treatment retention, though methadone may have slightly better retention rates.

Dose: 16 mgDuration: 1, 3, 6, 12, and 24 monthsForm: Sublingual
Management of Kratom withdrawal
Individuals with Kratom dependenceCase series and systematic literature review
PUBMEDLow

Buprenorphine is effective in managing Kratom withdrawal symptoms.

Dose: 16 mg
Forms
Sublingual
Commonly used for opioid use disorder treatment.
Subcutaneous Depot
Weekly or monthly formulations for sustained release.
Transdermal Patch
Used for chronic pain management.

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