Black Seed Oil (Nigella Sativa)

Black Seed Oil is a thymoquinone-rich oil known for its anti-inflammatory, antioxidant, & immune-modulating properties, with evidence supporting its use for asthma, blood pressure, blood glucose control, & immune enhancement.

anti-inflammatoryimmunecardiovascularrespiratory

Evidence last reviewed: 05 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cardiovascular

Blood PressureHDL CholesterolLDL CholesterolTriglycerides

Metabolic

Blood GlucoseHbA1c

Inflammation

IL-6TNF-α

Immune

Immune Function

Evidence

5 records

blood pressure

general population • Systematic review

PUBMEDModerate

Supplementation with Nigella sativa was associated with reductions in blood pressure.

Dose: 2000 mg

Citation: Sahebkar et al. (2016). A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure.

inflammatory cytokine profiles

pediatric systemic lupus erythematosus patients • RCT

PUBMEDModerate

Nigella sativa showed effects on disease activity & inflammatory cytokine profiles.

Dose: 2000 mg

Citation: Barlianto et al. (2024). Effects of black seed (Nigella sativa L.) on disease activity, T lymphocytes and inflammatory cytokine profiles in pediatric systemic lupus erythematosus: A randomized controlled trial.

symptoms of seasonal allergy

general population • RCT

PUBMEDModerate

Standardized Nigella sativa oil reduced symptoms of seasonal allergy.

Dose: 2000 mgForm: Standardized oil

Citation: Majeed et al. (2024). A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy.

glycemic control

type 2 diabetic patients • Systematic review

PUBMEDModerate

Nigella sativa supplementation showed potential benefits in improving glycemic control.

Dose: 2000 mg

Citation: Askari et al. (2019). Effect of Nigella sativa (black seed) supplementation on glycemic control: A systematic review and meta-analysis of clinical trials.

plasma lipid concentrations

humans • Systematic review

PUBMEDModerate

Nigella sativa was found to have a positive effect on plasma lipid concentrations.

Dose: 2000 mg

Citation: Sahebkar et al. (2016). Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials.

Forms

Oil

Commonly used in liquid form for oral consumption.

Capsule

Encapsulated oil for easier dosing and consumption.

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