Alpha-GPC

Choline donor supporting acetylcholine synthesis; evidence for acute cognitive function & power output in athletes.

focuscognitionstrengthpower

Evidence last reviewed: 04 Apr 2026

Buy this ingredient ← Back

Trade-offs & context

Known concerns, timing considerations, & interactions

Cardiovascular

Elevated TMAO (cardiovascular risk metabolite) signal from high choline intake — early and debated data

Neural

Headache possible at high doses

Context: doses >1200mg

Interaction

Excess cholinergic stimulation if stacked with CDP-Choline or Huperzine A

Dot colour: ●High concern ●Moderate ● Low / note

Biomarkers studied

Outcomes directly measured across the evidence records below

Cognitive

Cognitive Function

Performance

Power Output

Evidence

1 record

Power output / cognitive speed

Healthy adults; athletes • RCTs

PUBMEDModerate

Modest but consistent increases in peak power; some cognitive speed improvements.

Dose: 400 mgDuration: Acute to 6 weeks

Citation: Bellar et al. 2015; Ziegenfuss et al. 2008

Often used pre-workout 30–45 min before exercise.

Forms

Alpha-GPC 50% or 99%

Higher concentration = lower dose by weight.

Stacks containing Alpha-GPC

Public community stacks that include this ingredient.

Explore all stacks →

cognitivefocusnootropic

Enhanced Cognitive Focus

by@athlete

This stack combines acetyl-l-carnitine & alpha-gpc to enhance cognitive performance & focus. Acetyl-l-carnitine supports mitochondrial function & energy production in the brain, while alpha-gpc provides choline, a precursor to acetylcholine, a neurotransmitter involved in memory & learning.

Acetyl-L-Carnitine

1000mg

Alpha-GPC

300mg

New

View