Agmatine Sulfate

Agmatine sulfate is an endogenous metabolite of arginine that may help reduce neuropathic pain and enhance mood. It is potentially beneficial for individuals with neuropathic conditions and those seeking cognitive benefits.

neuroprotectionpainmoodnootropiccognitive

Evidence last reviewed: 20 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cognitive

Neuroprotection / NGF

Evidence

2 records

Neuropathic pain reduction

Participants with painful small fiber neuropathy • Case series

PUBMEDLow

Agmatine sulfate was found to be effective in reducing neuropathic pain in participants with painful small fiber neuropathy.

Dose: 2670 mgDuration: 2 monthsForm: AgmaSet® capsules

Citation: Rosenberg et al. (2020). Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. Nutrients.

Neuroprotection

Participants with herniated lumbar disc-associated radiculopathy • RCT

PUBMEDModerate

Agmatine sulfate showed potential neuroprotective effects in participants with lumbar disc-associated radiculopathy.

Dose: 1000 mgDuration: 10 days

Citation: Keynan et al. (2010). Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. MMWR.

Initial open-label dose escalation study followed by a double-blind trial.

Forms

Capsule

Commonly available as AgmaSet® capsules containing G-Agmatine® brand of agmatine sulfate.

Powder

Can be mixed with liquids for easier consumption.

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