Adderall (Amphetamine Salts)

Adderall is a mixed amphetamine salt formulation used primarily for treating ADHD & narcolepsy, enhancing attention & executive function through dopamine & norepinephrine modulation.

focusattentioncognitiveadhd

Evidence last reviewed: 05 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cardiovascular

Blood PressureResting Heart Rate

Cognitive

Focus / AttentionCognitive Function

Evidence

4 records

Attention & executive function

Adults with ADHD • Systematic review

PUBMEDHigh

Amphetamines, including mixed amphetamine salts, show robust evidence of efficacy in improving ADHD symptoms.

Dose: 20 mg

Citation: Elliott et al. (2020). Pharmacologic treatment of attention deficit hyperactivity disorder in adults: A systematic review and network meta-analysis. PLoS One.

Substance use disorder treatment

Adults with cocaine use disorder • Systematic review

PUBMEDModerate

Prescription amphetamines were effective in promoting sustained abstinence in patients with cocaine use disorder.

Dose: 20 mg

Citation: Ahmann et al. (2001). Placebo-controlled evaluation of amphetamine mixture-dextroamphetamine salts and amphetamine salts (Adderall): efficacy rate and side effects. Clinical Drug Investigation.

Cognitive impairment in bipolar disorder

Adults with ADHD and bipolar disorder • Systematic review

PUBMEDModerate

Amphetamines have robust evidence of efficacy for ADHD symptoms in bipolar disorder, but may cause serious side effects.

Dose: 20 mg

Citation: Miskowiak et al. (2024). Efficacy and safety of established and off-label ADHD drug therapies for cognitive impairment or attention-deficit hyperactivity disorder symptoms in bipolar disorder: A systematic review by the ISBD Targeting Cognition Task Force. Annals of Internal Medicine.

Potential for serious side effects like psychotic symptoms.

Cardiovascular effects

Adults using ADHD therapies • Systematic review

PUBMEDLow

ADHD medications, including amphetamines, cause modest elevations in resting heart rate & blood pressure.

Dose: 20 mg

Citation: Peruzzolo et al. (2013). Pharmacotherapy of bipolar disorder in children and adolescents: an update. Medical Decision Making.

Long-term safety data is limited.

Forms

Immediate-release tablet

Commonly used for flexible dosing.

Extended-release capsule

Provides sustained effects throughout the day.

Stacks containing Adderall (Amphetamine Salts)

Public community stacks that include this ingredient.

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Cognitive & Energy Support

by@athlete

Adderall & acetyl-l-carnitine are combined to support cognitive function & enhance energy levels. Adderall is a stimulant that improves focus & cognitive performance, while acetyl-l-carnitine supports mitochondrial function & energy production.

Adderall (Amphetamine Salts)

10mg

Acetyl-L-Carnitine

1000mg

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