Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

5-MeO-DMT

5-MeO-DMT is a potent psychedelic tryptamine known for its rapid & intense effects, with preliminary evidence suggesting it may reduce symptoms of depression, anxiety, & PTSD.

mental-healthdepressionanxietyneuroplasticity

Evidence last reviewed: 05 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cognitive

AnxietyMood / WellbeingPerceived Stress

Evidence

7 records

Depression

Adults with moderate symptoms of depression • RCT

PUBMEDModerate

Sublingual microdoses of 5-MeO-DMT were found to be safe & well-tolerated.

Dose: 15 mgForm: Sublingual

Citation: Bistue Millón et al. (2025). Safety and tolerability of multiple sublingual microdoses of 5-MeO-DMT in adults with moderate symptoms of depression and/or anxiety: a randomized, double-blind, placebo-controlled study.

Altered states of consciousness

Healthy participants • RCT

PUBMEDModerate

Intranasal administration of 5-MeO-DMT induced significant altered states of consciousness.

Dose: 15 mgForm: Intranasal

Citation: Rucker et al. (2024). Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-MeO-DMT) in healthy participants.

Depression & anxiety

General population • Systematic review

PUBMEDLow

Observational studies suggest rapid & sustained reductions in symptoms of depression & anxiety following 5-MeO-DMT use.

Dose: 15 mg

Citation: Rached et al. (2026). Safety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances: Potential Drug Interactions and Substance Use Disorder Treatment Data.

Depression symptoms

Adults with moderate depression • RCT

PUBMEDModerate

5-MeO-DMT administration led to rapid reductions in depression symptoms.

Dose: 10 mgDuration: Single sessionForm: Sublingual

PTSD symptoms

Adults with PTSD • Systematic review

PUBMEDLow

Observational studies suggest potential benefits in reducing PTSD symptoms.

Dose: 15 mg

Citation: Reckweg et al. (2022). The clinical pharmacology and potential therapeutic applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT).

Further research is needed to confirm these findings.

Anxiety symptoms

Adults with moderate anxiety • RCT

PUBMEDModerate

Participants reported significant reductions in anxiety symptoms following 5-MeO-DMT administration.

Dose: 10 mgDuration: Single sessionForm: Sublingual

Safety & tolerability

Healthy participants • Phase 1 trial

PUBMEDModerate

5-MeO-DMT was generally well tolerated with few serious adverse events.

Dose: 15 mgDuration: Single sessionForm: Intranasal

Forms

Sublingual

Commonly used for microdosing.

Intranasal

Used in clinical trials for rapid onset.

Vaporized

Traditional method for intense, short experiences.

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